Posts Tagged ‘menopause’


Hormone Update: Your Lifeline for Midlife and Beyond

Tuesday, November 9th, 2010

Please join us for a presentation and conversation presented by Dr. Ricki Pollycove – popular author and women’s integrated wellness specialist for over 30 years.

Bioidentical Hormones

What is menopause? What’s “normal” to expect? Must I suffer through these hot flashes and night sweats? Why can’t I sleep? Is it all in my head? Are hormones safe? Are they necessary?

Many questions about menopause persist. With the right support, good information on which to base good decisions, confidence in your knowledge and a clear understanding of the role of bioidentical hormones, this phase of life can be one of your best.

You’ll get details, updates and information on the latest science of women’s health, menopause and hormones in a relaxed, comfortable atmophere as Dr. Pollycove shares highlights from her new book.

Share in a holiday boutique of fancy foods with gourmet jams and relishes created by Kitty Meyers of Aunt Kitty’s Kreations and Artisan Gourmet Chocolates made in Switzerland shared by Lorraine Thomson, Owner of Truffuli di Pellegrini.

Wine and nibbles hosted by Healthwell Physical Therapy Group whose commitment to integrated health continues to expand and benefit you!

DATE: Monday, December 6, 2010
TIME: 6:30 – 8:30 pm
LOCATION: Healthwell Physical Therapy Group
1200 Gough Street, Lobby Level, San Francisco, CA 94109 (Map)
FREE PARKING: Available at Healthwell’s facilities
RSVP: Seating is limited. Please call Healthwell to RSVP
by December 2nd at 415.921.1211



Download the flier (PDF)

Meet Dr. Ricki Pollycove this weekend at Day in the Dogpatch

Friday, November 5th, 2010

Sunday, November 7th, 2010 | 11:00 am – 4:00 pm

Stop by Acupuncture Kitchens’ Day in the Dogpatch event this weekend and meet author Dr. Ricki Pollycove, integrated women’s wellness specialist for over 30 years. Have your chance to inquire about her recent book The Pocket Idiot’s Guide to Bioidentical Hormones.

Are you…Having hot flashes or night sweats? Losing sleep? Lost your desire for sex? More aches and pains? Stiff joints? Is it in your head? Or is it menopause? Confused? Scared? Worried about cancer, dementia or heart attack?
What’s a Woman to do?

Midlife and beyond: there is a lot to know to help you make good decisions and go forward with confidence. Get the depth and details of good science presented in a very digestable format.

You can find more information about the Day in the Dogpatch on Facebook. Event starts at 11:00am and pie judging starts at 3:00pm.

Hormone Breast Cancer Fear

Monday, November 1st, 2010

Many healthcare professionals have been asking for the opinions and/or responses of menopause experts to the recent JAMA article.

My comments echo those of my colleague, Dr. Alan Altman, as well as those of Wulf Utian, MD, founder and long-time executive director of the North American Menopause Society who recently stepped down from that post after 30 years.

  1. This is from the same WHI Study (2002) with one drug, Prempro, in one dose only, given to women average age 63.5 years with a body mass index (BMI) of 28.5 (significantly overweight) when the study began, age 68.5 years with the increased BMI of 30 upon its conclusion 5 years later (obese, a significant increase in risk for breast cancer). The wrong drug, in the wrong doses, to the wrong women. Yet misleadingly presented as if the results applied to the newly menopausal symptomatic women, which they do not.
  2. This study has absolutely NO impact on you if you are not taking Prempro! That means none of my patients are represented in this study.
  3. As the WHI has previously shown years ago, and repeated in this study, there is a very small increase in the risk of occurrence of breast cancer when taking Prempro, which as of late did not reach statistical significance (important detail to understand). This small increase was not seen in the Premarin (estrogen-only) part of the study. In fact, in the Premarin-only part of the study, regardless of their age, the women who were greater than 80% compliant with their use of the drug… meaning they took their dose as they were supposed to… had a statistically significant 23% decreased risk of breast cancer!
  4. This emphasizes once again that something about the progestin used in Prempro, called MPA, helped cause the small increase in breast cancer not seen in the Premarin-only arm. This has been shown in many other studies over the past 30 years:
    • estrogen alone = no increase in breast cancer risk, likely small decrease in risk
    • estrogen plus MPA = small increase in breast cancer risk (8/10,000 women years of getting diagnosed, 1/10,000 excess breast cancer death attributed to PremPro with 11 years of use shown in this current data set)

    This is another small but important reason why most clinicians do not use MPA (Provera brand name) any longer, and haven’t for some time (due to slightly adverse effects on risk markers for heart disease and a slight increase in breast cancer as well).

    Natural progesterone (brand name Prometrium) has NOT been shown to elevate risk for breast cancer when used with estrogen.

  5. The increase in the risk of death from breast cancer while taking Prempro compared to placebo, in this newest report, was one woman per 10,000 women per year…a level described as “extremely rare” by the FDA.
  6. Every study adds a piece to the big picture. The big picture emerges over time, with all ages of women, body types and life styles to create a deeper understanding of benefits and risks; the real associations or outcomes over time. Unfortunately, the media treats each piece as a compelling new revelation, creating confusion and potential for panic. In discussing this study, there has been little media attempt to put it into context so women can better understand the whole picture of risk vs. benefit of taking this drug or any other Hormone Therapy (HT) for menopause. Benefits of HT, shown in WHI and many other studies prior to as well as since WHI, in the appropriate women using the appropriate doses of the appropriate HT begun at the appropriate time, include a decreased risk of heart attack (by far the biggest killer of women each year), diabetes, osteoporotic fracture, colon cancer, and the risk of dying from any cause at all (total mortality). These potential benefits are above and beyond the symptom relief of hot flashes, joint pains, night sweats, sleep disorders, palpitations, headaches, low mood, low libido, vaginal dryness and pain with intercourse commonly associated with menopause. A watermelon sized benefit, a watermelon seed sized risk when prescribed appropriately.
  7. Within this context of risk vs. benefit, as with any medication or drug, a woman can properly discuss her own individual situation with her doctor or nurse practitioner and make educated decisions without the fear and panic that come from sensationalized news reports and media coverage.
  8. There is a growing body of data demonstrating that the use of non-oral estrogen, via patch, gel, or vaginal ring, is safer to use than estrogen pills by mouth, taking away the risk of blood clots, and stroke from blood clots, seen with the pills used in WHI, as well as other benefits.
  9. Talk with your clinician when time allows and remain confident that this “new” Prempro story is likely not to be of any meaningful significance to you. Your quality of life is very important and should be carefully addressed at all stages of your life. Over 50 years of excellent observational data on newly menopausal women in the US, Canada, Great Britain and Europe, billions of women years of use, are not invalidated by this or any other study.

Wulf Utian response

What is it about the WHI writing team that they can take data that they agree is not statistically significant, then reach the unjustified conclusion that with hormones as used in the WHI study, “breast cancer mortality also appears to be increased with combined use of estrogen plus progestin,” and finally through their lead author and others advise women that HT is really dangerous?

So what are the facts?

As with the initial publications, this longer follow up approximately 7 years after the original WHI EPT trial termination in July 2002, confirms a slight increase in incidence of breast cancer in women on combined continuous estrogen plus progestin therapy compared to placebo. Again, as in the first reports, there was a greater incidence of node positive cancers. The original reports confirmed no increase in overall all-cause mortality, but did not report separately on breast cancer deaths. At first blush, this paper would seem to be one leading to more banner headlines against use of postmenopausal hormone therapy, reporting that “breast cancer mortality also appears to be increased with combined use of estrogen plus progestin.” However, one needs to read the paper carefully. There were 25 deaths in the HT group and 12 deaths with the placebo. The HR (hazard ratio) was 1.96 which is almost a doubling of the relative risk (I can just see the headlines – HT doubles risk of dying in postmenopausal women). But the CI (confidence interval) was 1.00-4.04. This wide spread includes 1.00 which makes the difference NOT statistically significant. Hence their statement in their conclusions that mortality “APPEARS to be increased.” For this reason it is totally appropriate to look at the absolute risk. This turns out to be 2.6 vs. 1.3 deaths per 10,000 women per year. By the WHO CIOMS classification, even if this was statistically significant, the increased risk would be classified as extremely rare.

So what do I take away from this? Firstly, the combined continuous use of estrogen plus progestin (at least the products used in the WHI) have an adverse effect on the breast, slightly increasing both the incidence of BC and possibly the chance of dying from it. While this increased risk is rare, it is mandatory on health providers to try “to do no harm” (Hippocratic oath). Fortunately, the good news is that the same WHI investigators just reported at the Asia-Pacific Menopause Society meeting in Sydney that estrogen when administered alone appears to have the opposite effect. That is, they apparently reported that the E alone group had a lower incidence of BC and mortality from BC compared to placebo. I await that publication with interest (but where and when will WHI publish good news?).

Secondly, the NIH and their WHI Writing Group should finally come out with a revised “Global Health Index” targeted specifically at the 50-59 year old group of women because they are the most likely to suffer from severe hot flashes and be prescribed hormones. If benefit on heart, bone, colon, diabetes, and possibly brain is taken into account, the balance of benefit to risk is likely to be quite different from all their previous looks at that score.

The conclusion is therefore that at least the progestin (MPA – medroxyprogesterone acetate) used in the WHI study is not beneficial to the breast and may cause harm. Other studies appear to indicate that alternate progestins or progesterone used in lower doses and intermittently may be safer, but there are no other studies of the size of the WHI and never likely to be.

Bottom line is that after all the hullabaloo over the past 9 years since the initial termination of the HT arm of the WHI, estrogen turns out to be quite safe, the MPA has a cloud of suspicion, and the future recommendation is for careful assessment on an individual basis for every women transiting menopause to determine health status, future risk for disease, and a decision based on a clear indication whether hormones are truly needed and recommended in her situation. If the affirmative, then current knowledge should be used to determine what dose, type, and route of administration should be used.

The WHI has succeeded finally in showing that postmenopausal hormone therapy has clear risks and rewards. The risks are rare, and it is up to every women for herself to decide based on a transparent explanation to her about the facts.

May I conclude that there is no better source for her to get these facts in a clear and unbiased way than from the NAMS website at www.menopause.org.

NAMS response

Knowing All the Facts About the New HRT Study

Friday, October 22nd, 2010

The single largest barrier to women taking ET/HT and allowing themselves to feel better after menopause is the fear of breast cancer.  Informed physicians can’t just sit by and allow the media to get this important story wrong.

The study just released regarding hormone replacement therapy (HRT) and breast cancer released October 20th (from WHI group Chlebowski et al) has been met with fearful reactions by the news media, but what can we learn from this new study? For one thing, the absolute risk is exactly what we knew from before. There is a .008% increase risk for a breast cancer diagnosis with an increase risk of death from breast cancer of a .012%. These are very tiny individual risks. 

The new information is in the details of breast cancer cell types associated with Medroxyprogesterone Acetate (MPA, the progestin found in Prempro), and the incidence of higher death rates. The problem remains with MPA. The estrogen alone trial of the WHI study showed a 23% decreased risk if being diagnosed with breast cancer.

As of today we even have very reassuring data about estradiol and natural progesterone not statistically increasing risk for breast cancer and also showing much better survival if one does get a breast cancer diagnosis if the woman is on estradiol at the time of diagnosis. The detail of which hormones a woman takes is very important. We must help make women aware of news about different products that does not relate to their risk status, unless they choose to be on Prempro for 11+ years.

I have never given any age of a woman a Premarin or PremPro prescription for a new start of hormone replacement therapy for the management of menopausal symptoms. There are many better options and that is the bottom line for this article as well. Simply look at transdermal estrogens, all biologically identical to that which we naturally make in our bodies and for which nature selected over millions of “randomized blinded trial years” (the process of natural selection at its finest in my opinion). In all sorts of research, at cellular levels, as well as gene regulation and gene suppressions/expression studies, estradiol is very positive in its effects on cell differentiation; in essence, keeping healthy breast cells healthy. That is the goal of ideal hormone support for every tissue we study: the enhancement of balanced regulated cell growth and positive anti-oxidant effects of estradiol.

New Book on Estrogen Use in Menopause Sheds Light on the Risks and Benefits of Hormone Replacement Therapy and Bioidentical Hormones

Wednesday, March 10th, 2010

San Francisco Gynecologist’s Book Helps Women Figure Out What’s Right for Them

Every week it seems like there is new and many times conflicting information about hormone therapy for menopausal women. Now, thanks to a leading gynecologist at a prestigious San Francisco medical center, women can clear up the confusion and take an unbiased look at bioidenticals, the newer, safer hormones that are exact copies of those made in a woman’s body.

Dr. Ricki Pollycove’s Pocket Idiot’s Guide to Bioidentical Hormones is newly published by Alpha Books, a division of Penguin Group, Inc. It is available for $9.95.

This mighty little myth-buster of a book changes attitudes towards estrogen use in menopause. Estrogen use became the center of a storm of controversy in 2002. The resultant confusion strikes at the heart of Baby Boomer women’s confidence about healthy aging and hormones.

With this punchy pocket guide women will abandon old fears about estrogen and get the full benefit of hormone support for total body health.

The books helps women learn about:

–The wise use of estrogen lowers a woman’s risk of breast and colon cancer, heart disease, osteoporosis, spine and hip fractures, and dementia. Even skin cancer outcomes are better in women who take estrogen.

–Because of old fears opportunities for better health are lost by over 80 percent of American women for whom hormone supplements are appropriate.

–Beauty experts agree that estrogen makes for better skin and body tone. Estrogen is better for the internal organ systems as well.

–Women will benefit from appropriate estrogen support throughout the many stages of the menopause transition

–Time-tested truths are revealed through reanalysis of trust worthy data on millions of women (2007 -2009 WHI writer’s group publications and world medical literature in English).

This is a book that bridges the gap between heightened consumer expectations and American-trained physicians. Women will be well-informed for a productive conversation with their doctors and get the hormonal support they need to prevent disease and age with vitality and strength.

Backgrounder on the book

Estrogen is one of the secrets to healthy aging. Controversy has paralyzed millions of women making the decision whether or not to take estrogen to treat the troubling symptoms caused by low estrogen in menopause. Each cell in the body functions better when estrogen levels are at a critical minimum—curiously about the level present in men across their life span. Yes, men do have estrogen and part of their better bones and less wrinkled skin is due to this profound difference in hormone production.

Wise use of estrogen can lower a woman’s risk of osteoporosis, hip fractures, heart disease, colon cancer and dementia. Yet fewer than 17 percent of American women for whom hormone supplements are appropriate are actually taking them. This lack of use reflects consumer mistrust of the pharmaceutical industry and organized medicine in general, accentuated by fears regarding breast cancer. Conflicting reports in the medical literature have only amplified the confusion. The first 5 to 10 years of menopause is the window of opportunity for reducing risks for disease with estrogen. Overcoming fears from false alarms, lingering mistrust of estrogen, may be the biggest disease prevention decision a woman can make in midlife.

Bioidentical hormones are hormones created from plant molecules, transformed into hormones identical to those found in the human body, atom for atom. These newly available hormone products, manufactured to the highest pharmaceutical standards, broaden the treatment options, providing women with another resource to meet the needs of aging with improved safety.

The Pocket Idiot’s Guide™ to Bioidentical Hormones provides the evidence on what is safe and what is not. The Guide presents a wide range of options for supplementing hormones, within an easy-to-answer discussion of Hormone Therapy in general. Synthesizing vast research data, the book answers an extensive list of questions. Coverage includes:

  • What exactly are bioidentical hormones, how they are made and monitored
  • The clear cut case for hormones—bioidentical or otherwise
  • The safety issues—which bioIdentical hormones work, which don’t really help much, and which situations are not best
  • Bioidentical hormones beneficial effect on the heart, bones, and brain
  • Creating an individualized health plan—which hormones, in what combination—how much and how often

Backgrounder on Ricki Pollycove

Original thinker and contrarian, Dr. Ricki Pollycove has spent a career spanning over 30 years dedicated to women’s health, breast cancer advocacy and healthy aging. With her broad perspective on women’s wellness she brings together powerful facts that support taking hormones for optimal health. She has been an active Obstetrician-Gynecologist since 1981, with her gynecology practice in San Francisco, California. She is a Fellow of the American College of Obstetrics and Gynecology, a member of the North American Menopause Society, the American Society of Breast Diseases, the San Francisco Medical Society and is the founding Director for Education of the CPMC Breast Health Center and a past chief of the division of Gynecology at the California Pacific Medical Center. She earned her MD from the University of California, San Francisco, School of Medicine, a Masters of Science from the University of California, Berkeley and a Bachelor’s degree, also from UC Berkeley, in Zoology and Immunology. She is a volunteer clinical faculty at the UCSF School of Medicine, and has taught Integral Physiology and Anatomy in the Integral Health Studies Master’s Program at CIIS. She serves on two non-profit boards, the Sophia Project for mothers and children at risk as well as the California Institute of Integral Studies, a university devoted to East-West integral education in San Francisco.